Your Amazing Molecular Machines – VIDEO



Your Amazing Molecular Machines

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Your Amazing Molecular Machines – VIDEO



These are the molecular machines inside your body that make cell division possible. Animation by Drew Berry at the Walter and Eliza Hall Institute of Medical Research. http://wehi.tv

Special thanks to Patreon supporters:
Tony Fadell, Donal Botkin, Curational, Jeff Straathof, Zach Mueller, Ron Neal, Nathan Hansen, Corvi

Support Veritasium on Patreon: http://ve42.co/patreon

Every day in an adult human roughly 50-70 billion of your cells die. They may be damaged, stressed, or just plain old – this is normal, in fact it’s called programmed cell death.

To make up for that loss, right now, inside your body, billions of cells are dividing, creating new cells.

And cell division, also called mitosis, requires an army of tiny molecular machines.DNA is a good place to start – the double helix molecule that we always talk about.

This is a scientifically accurate depiction of DNA. If you unwind the two strands you can see that each has a sugar phosphate backbone connected to the sequence of nucleic acid base pairs, known by the letters A,T,G, and C.

Now the strands run in opposite directions, which is important when you go to copy DNA. Copying DNA is one of the first steps in cell division. Here the two strands of DNA are being unwound and separated by the tiny blue molecular machine called helicase.
It literally spins as fast as a jet engine! The strand of DNA on the right has its complimentary strand assembled continuously but the other strand is more complicated because it runs in the opposite direction.
So it must be looped out with its compliment strand assembled in reverse, section by section. At the end of this process you have two identical DNA molecules, each one a few centimeters long but just a couple nanometers wide.

To prevent the DNA from becoming a tangled mess, it is wrapped around proteins called a histones, forming a nucleosome.
These nucleosomes are bundled together into a fiber known as chromatin, which is further looped and coiled to form a chromosome, one of the largest molecular structures in your body.
You can actually see chromosomes under a microscope in dividing cells – only then do they take on their characteristic shape.

The process of dividing the cell takes around an hour in mammals. This footage is from a time lapse. You can see how the chromosomes line up on the equator of the cell. When everything is right they are pulled apart into the two new daughter cells, each one containing an identical copy of DNA.
As simple as it looks, this process is incredibly complicated and requires even more fascinating molecular machines to accomplish it. Let’s look at a single chromosome. One chromosome consists of two sausage-shaped chromatids – containing the identical copies of DNA made earlier. Each chromatid is attached to microtubule fibers, which guide and help align them in the correct position. The microtubules are connected to the chromatid at the kinetochore, here colored red.
The kinetochore consists of hundreds of proteins working together to achieve multiple objectives – it’s one of the most sophisticated molecular mechanisms inside your body. The kinetochore is central to the successful separation of the chromatids. It creates a dynamic connection between the chromosome and the microtubules. For a reason no one’s yet been able to figure out, the microtubules are constantly being built at one end and deconstructed at the other.
While the chromosome is still getting ready, the kinetochore sends out a chemical stop signal to the rest of the cell, shown here by the red molecules, basically saying this chromosome is not yet ready to divide
The kinetochore also mechanically senses tension. When the tension is just right and the position and attachment are correct all the proteins get ready, shown here by turning green.
At this point the stop signal broadcasting system is not switched off. Instead it is literally carried away from the kinetochore down the microtubules by a dynein motor. This is really what it looks like. It has long ‘legs’ so it can avoid obstacles and step over the kinesins, molecular motors walking the other direction.

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Video Title – Your Amazing Molecular Machines
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  • @chrissweezey1 Christopher Sweezey January 15, 2018
    I added a video to a @YouTube playlist http://youtu.be/X_tYrnv_o6A?a  Your Amazing Molecular Machines
  • @motorcycle_live hi-tech January 10, 2018
    Your Amazing Molecular Machines https://youtu.be/X_tYrnv_o6A https://twitter.com/MIT/status/950790558666100742 …
  • @tokyojerry Jerry Suppan January 1, 2018
    I liked a @YouTube video http://youtu.be/X_tYrnv_o6A?a  Your Amazing Molecular Machines
  • @alexssandro2 Alexssandro Meneses December 28, 2017
    Liked on YouTube: Your Amazing Molecular Machines https://youtu.be/X_tYrnv_o6A 
  • @PetrusJPrinsloo Petrus Prinsloo December 27, 2017
    This just blows my mind. To think this is how we age, by the machines making mistakes in the copying. Or cancer, where the sun does damage to the DNA and then broken machines get built. Your Amazing Molecular Machines https://youtu.be/X_tYrnv_o6A 
  • @GGunit84 Mauricio Giraldo December 23, 2017
    Your Amazing Molecular Machines https://fb.me/42CTiy70I 
  • @GGunit84 Mauricio Giraldo December 23, 2017
    I liked a @YouTube video http://youtu.be/X_tYrnv_o6A?a  Your Amazing Molecular Machines
  • @openmindedatma Praveen December 23, 2017
    Mindboggling, when you contemplate these things. "Your Amazing Molecular Machines" https://youtu.be/X_tYrnv_o6A  via @YouTube
  • @JMPn33 Shiki December 22, 2017
    Your Amazing Molecular Machines https://youtu.be/X_tYrnv_o6A  via @YouTube
  • @Regular_Clasher Eiz December 22, 2017
    I liked a @YouTube video http://youtu.be/X_tYrnv_o6A?a  Your Amazing Molecular Machines


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Revolutionary: Michael Behe and the Mystery of Molecular Machines – VIDEO



As we know, random changes and unguided natural processes routinely succeed in assembling functional equipment for a range of uses. Wait…it doesn’t work that way?

The Revolutionary Behe website, at http://revolutionarybehe.com/, features more information about Dr. Behe’s research, other molecular machines, and evidence for intelligent design, and the stories of revolutionary scientists changing the evolutionary paradigm. See the documentary now and pass it along!

============================
The Discovery Science News Channel is the official Youtube channel of Discovery Institute’s Center for Science & Culture. The CSC is the institutional hub for scientists, educators, and inquiring minds who think that nature supplies compelling evidence of intelligent design. The CSC supports research, sponsors educational programs, defends free speech, and produce articles, books, and multimedia content. For more information visit https://www.discovery.org/id/
http://www.evolutionnews.org/
http://www.intelligentdesign.org/

Follow us on Facebook and Twitter:
Twitter: @discoverycsc
Facebook: https://www.facebook.com/discoverycsc/

Visit other Youtube channels connected to the Center for Science & Culture
Discovery Institute: https://www.youtube.com/user/DiscoveryInstitute
Dr. Stephen C. Meyer: https://www.youtube.com/user/DrStephenMeyer
The Magician’s Twin – CS Lewis & Evolution: https://www.youtube.com/user/cslewisweb
Darwin’s Heretic – Alfred Russel Wallce: https://www.youtube.com/user/AlfredRWallaceID

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Video Title – Revolutionary: Michael Behe and the Mystery of Molecular Machines
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  • @HouseformA Houseform Apologetics January 11, 2018
    Revolutionary: Michael Behe and the Mystery of Molecular Machines: http://youtu.be/RgYhCAwgXwc?a  via @YouTube
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    I liked a @YouTube video http://youtu.be/7ToSEAj2V0s?a  Revolutionary: Michael Behe and the Mystery of Molecular Machines
  • @gerhardl Gerhard Lingenberg December 9, 2017
    Revolutionary: Michael Behe and the Mystery of Molecular Machines https://youtu.be/7ToSEAj2V0s  via @YouTube
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    Revolutionary: Michael Behe and the Mystery of Molecular Machines https://youtu.be/7ToSEAj2V0s 
  • @teppaniaki Teemu Långsjö December 3, 2017
    Tiedätkö, mistä ID:ssä on kyse? Älä luota huhupuheisiin tai tietämättömien huuteluihin. Selvitä itse onko ID:ssä järkeä vai onko se huuhaata. Katso video: Revolutionary: Michael Behe and the Mystery of Molecular Machines https://youtu.be/7ToSEAj2V0s 
  • @sosalpha David Pereschuk December 2, 2017
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    Revolutionary: Michael Behe and the Mystery of Molecular Machines https://www.youtube.com/watch?v=7ToSEAj2V0s&feature=share …


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The Nobel Prize in Chemistry: Molecular Machines, Explained – Speaking of Chemistry – VIDEO



The 2016 Nobel Prize in Chemistry goes to Jean-Pierre Sauvage, Sir Fraser Stoddart, and Ben Feringa. Read all about it: http://cen.acs.org/articles/94/web/2016/10/Molecular-machines-garner-2016-Nobel-Prize-in-Chemistry.html
↓↓More links and references below↓↓

In this episode of Speaking of Chemistry, we look at how three molecular machinists earned this year’s Nobel Prize in Chemistry. Apologies to our international posse: All times referenced in this video are based on us being in the Eastern Time Zone.

For more information on the prize check out:
1.)C&EN’s coverage: http://cen.acs.org/articles/94/web/2016/10/Molecular-machines-garner-2016-Nobel-Prize-in-Chemistry.html

2.)Nobelprize.org’s announcement: http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2016/press.html

Videos of the 4-wheeled molecule were used with permission from Macmillan Publishers Ltd.
Kudernac, T. et al. 2011, Nature 479, 208–211 http://dx.doi.org/10.1038/nature10587

Want even more molecular-mechanical goodness? You are in luck, my friend. Here are some more great references.

Rethinking Molecular Machines | C&EN
http://cen.acs.org/articles/90/i14/Rethinking-Molecular-Machines.html

Nanomachinery Gets A Lift | C&EN
http://cen.acs.org/articles/82/i12/NANOMACHINERY-LIFT.html

Nanocar Research Rolling Along | C&EN
http://2015.cenmag.org/nanocar-research-kept-rolling-along-html/#.V_UovvkrJQJ

A Nanocar With Four-Wheel Drive | C&EN
http://cen.acs.org/articles/89/web/2011/11/Nanocar-Four-Wheel-Drive.html

Molecular Pump Mimics Natural Carrier Proteins | C&EN
http://cen.acs.org/articles/82/i12/NANOMACHINERY-LIFT.html

Transition Metal-Containing Rotaxanes and Catenanes in Motion | Accounts of Chemical Research
http://pubs.acs.org/doi/full/10.1021/ar960263r

A molecular shuttle | JACS
http://pubs.acs.org/doi/abs/10.1021/ja00013a096

Light-driven monodirectional molecular rotor | Nature
http://www.nature.com/nature/journal/v401/n6749/abs/401152a0.html

A [3]Rotaxane with Two Porphyrinic Plates Acting as an Adaptable Receptor | JACS
http://pubs.acs.org/doi/abs/10.1021/ja7110493

A Three-Compartment Chemically-Driven Molecular Information Ratchet | JACS
http://pubs.acs.org/doi/abs/10.1021/ja302711z

Speaking of Chemistry is brought to you by Chemical & Engineering News, the news magazine of the American Chemical Society.

Find us on all these places:
Subscribe! http://bit.ly/ACSReactions
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Video Title – The Nobel Prize in Chemistry: Molecular Machines, Explained – Speaking of Chemistry
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Molecular machines win Nobel Prize – VIDEO



The Nobel Prize in Chemistry 2016 has been awarded to Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa for their design and production of molecular machines. Read more: http://ow.ly/UaZS304SnuR

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Video Title – Molecular machines win Nobel Prize
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